Chelidonium majus WATER EXTRACT INITIATES PLATELET AGGREGATION AND INHIBITS FIBRIN POLYMERIZATION IN BLOOD PLASMA

Chelidonium majus is a well-known source of biologically active compounds. Most them are alkaloids, which used in researches and for tradition medicine. In this study, we explored the influence C. crude total extract onto blood coagulation system vitro, primary secondary hemostasis. Aim. To study process. Methods. Turbidimetry plasma, APTT test with chromogenic substrates, platelet aggregation were work. Results. We demonstrated moderate stimulating effect on platelets (the rate increased up to 10%, followed by disaggregation). Extract also stimulated 12.5 mcM ADP. observed increase plasma clotting time presence extract, that corresponded 274, 411, 685, 1370 mcg dry from 70 s control 80, 90, 170 180 s, respectively, turbidimetry APTT-reagent. However, substrate thrombin (S2238) did not show significant plant’s activity. Conclusions. Thus, can conclude anticoagulant activity direct inhibition fibrin polymerization.